Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc10.5 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Splicing dysregulation is associated with aggresive and metabolic-associated liver disease-derived hepatocellular carcinoma

Sanchez Natalia Herman , Lopez-Canovas Juan L , del Rio-Morenos Mercedes , Amado Victor , de la Mata Manuel , Rodriguez-Peralvarez Manuel , Luque Raul M , Gahete Manuel D

Metabolic-associated fatty liver disease (MAFLD) is a growing cause of hepatocellular carcinoma (HCC), but the molecular mechanisms associated with the pathological progression from MAFLD to HCC are still to be fully elucidated. The genomic and transcriptomic profile of HCC samples have been widely described; however, the proteomic landscape of MAFLD-derived HCC samples is mostly unknown. Here, we sought to perform the first quantitative proteomic analysis of HCC samples from ...